As the pandemic, the war, bottlenecks in transport and production, limitations for travel impact the business world, many companies are forced to adapt their supply chain strategies to the increased volatility, uncertainty, complexity und ambiguity (VUCA). Based on many strategy projects in various industries, a new approach to define new supply chain strategies highlights possible solutions for this challenging task. Understanding customer requirements, adapting to company strategy and using strategy patterns help supply chain leaders to create competitive advantage through their supply chain strategy in their industry. The approach supports the development of skills and capabilities in the supply chain including using the latest digital tools. Examples from different industries illustrate how companies have adapted their strategy to the new challenges.